The first step is to install wine:
pacman -S wine
Once wine is installed, we need to set up the configuration:
winecfg
This will finish the wine setup.
Now we can install applications by doing:
wine program_installer.exe
This will then run through the regular installation process.
To uninstall a program, we can do:
wine-uninstaller
This will launch a GUI where you can add or remove programs.
Wine files and the C drive can be found in:
~/.wine/